Journal
NATURE
Volume 404, Issue 6773, Pages 87-91Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35003589
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The expression of dock genes in vertebrates is widespread and not restricted to classical dock structures(1,2). The expression of the Clock gene in zebrafish shows a strong circadian oscillation in many tissues in vivo and in culture, showing that endogenous oscillators exist in peripheral organs(3). A defining feature of circadian clocks is that they can be set or entrained to local time, usually by the environmental light-dark cycle(4,5). An important question is whether peripheral oscillators are entrained to local time by signals from central pacemakers such as the eyes or are themselves directly light-responsive. Here we show that the peripheral organ docks of zebrafish are set by light-dark cycles in culture. We also show that a zebrafish-derived cell line contains a circadian oscillator, which is also directly light entrained.
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