Journal
FEBS LETTERS
Volume 469, Issue 1, Pages 72-76Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01242-4
Keywords
TrkA-interacting protein; c-Abl tyrosine kinase; SH2-B; kinase activation loop
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The nerve growth factor receptor, TrkA, is essential For the survival and differentiation of neurons in the central and peripheral nervous systems, To understand the molecular principles underlying this differentiation step, we employed a yeast two-hybrid screening protocol using human TrkA as bait. We isolated c-Abl as a TrkA-interacting protein, in addition to known proteins such as phospholipase C gamma and SH2-B. This interaction was confirmed by an in vitro binding assay using glutathione S-tranferase-Abl fusion protein, Furthermore, ae show here that c-Abl binds to phosphotyrosine residue(s) in the kinase activation loop of TrkA. (C) 2000 Federation of European Biochemical Societies.
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