Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Volume 1477, Issue 1-2, Pages 98-111Publisher
ELSEVIER
DOI: 10.1016/S0167-4838(99)00263-0
Keywords
cathepsin; lysosome; cysteine protease; papain; structure-function regulation
Categories
Ask authors/readers for more resources
Lysosomal cysteine proteases were believed to be mainly involved in intracellular protein degradation, Under special conditions they have been found outside lysosomes resulting in pathological conditions. With the discovery of a series of new cathepsins with restricted tissue distributions, it has become evident that these enzymes must be involved in a range of specific cellular tasks much broader than as simple housekeeping enzymes. It is therefore timely to review and discuss the various physiological roles of mammalian lysosomal papain-like cysteine proteases as well as their mechanisms of action and the regulation of their activity. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available