Journal
ORGANIC LETTERS
Volume 2, Issue 5, Pages 639-642Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol991400y
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[GRAPHICS] Treatment of several 3-substituted indoles, including derivatives of tryptophan and serotonin, with commercially available Selectfluor in acetonitrile/water furnished 3-substiuted 3-fluorooxindoles in good to high yields. Since 3-fluorooxindoles obtained are sterically similar to both oxindoles and 3-hydroxyoxindoles, they should be useful as probes for investigating the enzymatic mechanism of indole biosynthesis and metabolism.
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