Journal
ANALYTICA CHIMICA ACTA
Volume 408, Issue 1-2, Pages 285-290Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0003-2670(99)00808-9
Keywords
beta(2)-agonists; retina; gas chromatography; mass spectrometry
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Accumulation of several drugs, including beta(2)-agonists, such as clenbuterol, in melanin-containing tissues (e.g retina or hair) has been demonstrated. This fact allows for retrospective monitoring of the usage of these growth promoters. Here, a multiresidue gas chromatography-mass spectrometry (GC-MS) method for the analysis of several beta(2)-agonist compounds in bovine retina is proposed. The method is based on solid phase extraction (SPE) using a mixed stationary phase and derivatisation with N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA). Recoveries estimated from spiked samples ranged between 27.0 (salbutamol) and 53.2% (tulobuterol); detection limit (DL) with a signal-to-noise ratio equal to 10 for the least abundant ion was fixed at 70 ng/g retina for all compounds. (C) 2000 Elsevier Science B.V. All rights reserved.
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