Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 296, Issue 5, Pages 1169-1173Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/jmbi.2000.3542
Keywords
cruciform conformation; Holliday junctions; DNA supercoiling; site-specific recombination; atomic force microscopy
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Funding
- NIGMS NIH HHS [GM 54991] Funding Source: Medline
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The interaction between specific sites along a DNA molecule is often crucial for the regulation of genetic processes. However, mechanisms regulating the interaction of specific sites are unknown. We have used atomic force microscopy to demonstrate that the structural transition between cruciform conformations can act as a molecular switch to facilitate or prevent communication between distant regions in DNA. Cruciform structures exist in vivo and they are critically involved in the initiation of replication and the regulation of gene expression in different organisms. Therefore, structural transitions of the cruciform may play a key role in these processes. (C) 2000 Academic Press.
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