Journal
BIOMEDICAL CHROMATOGRAPHY
Volume 22, Issue 4, Pages 343-353Publisher
WILEY
DOI: 10.1002/bmc.945
Keywords
benzofurazan; 2,1,3-benzoxadiazole; derivatization reagent; fluorescence; mass spectrometry; high-performance liquid chromatography
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Chemical derivatization is often used to enhance the delectability of the target compounds and to improve the separation efficiency in high-performance liquid chromatography (HPLC). In this review, we describe the recent progress in the development of derivatization reagents having a benzofurazan structure, namely, the fluorogenic reagents, water-soluble reagents, reagents for the analysis of peptides and proteins, and reagents for mass spectrometric detection. The application of these reagents to bio-samples is also briefly described. Copyright (c) 2007 John Wiley & Sons, Ltd.
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