Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 196, Issue 2, Pages 227-230Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(99)00428-7
Keywords
continuous flow rheometry; rheology; oscillatory testing; viscoelasticity; solid lipid nanoparticle dispersions (SLN)
Categories
Ask authors/readers for more resources
The rheological behaviour of solid lipid nanoparticle dispersions (SLN) prepared by high pressure homogenization was investigated using a Haake RS-100 rheometer. Four preparations differing in their lipid content and macroscopic consistency were tested by continuous shear rheometry and oscillatory testing. Rheological data from continuous shear measurement reveal plastic flow for systems with low lipid content as well as for systems with high lipid content. By using oscillatory testing more detailed information concerning the structure could be achieved. Rheological measurements of 40% lipid dispersions show viscoelastic properties comparable to the data from standard dermal preparations. Therefore high concentrated lipid dispersions might constitute a promising vehicle for topical administration. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available