Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 196, Issue 2, Pages 183-185Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(99)00417-2
Keywords
nanoparticles; high pressure homogenisation; SLN; nanoemulsions
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In this study a comparison of the influence of the homogenising equipment supplied by different manufacturers on the quality of the lipid nanodispersions is given. An Avestin EmulsiFlex-B3 (B3) and APV Micron Lab 40 (LAB 40) were used for high pressure homogenisation. Particle size and particle size distribution were chosen as qualify parameters. The influence of different process parameters was evaluated. The: two homogenisers were compared in their qualify of nanoparticles-production by hot and cold homogenisation technique and in processing nanoemulsions. Working with the B3 appeared as useful for preformulation studies and processing of expensive or rare drugs and excipients. This first scaling up within laboratory scale is evaluated and the problems and remarkable aspects working with the B3 are pointed out. (C) 2000 Elsevier Science B.V. All rights reserved.
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