Journal
TETRAHEDRON-ASYMMETRY
Volume 11, Issue 4, Pages 975-980Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0957-4166(00)00011-2
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The antispastic drug (R)-(-)-baclofen has been synthesized enantioselectively using a diastereoselective Michael addition reaction of the conjugate base of an enantiopure Fischer-type amino carbene to p-chloro-nitrostyrene. (C) 2000 Elsevier Science Ltd. All rights reserved.
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