Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 196, Issue 2, Pages 155-159Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(99)00411-1
Keywords
drugs; nanoparticles; polydispersity index
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The major problem of many newly developed pharmaceutical drugs is their poor solubility in water and simultaneously in organic media. To solve these problems formulation as nanosuspensions is an attractive alternative. During the drug development process screening for an optimal formulation by homogenisation is essential. Time and cost effective production in an initial phase of R&D can be conducted on lab scale by using the Micron Lab 40 in its discontinuous version. In this report reproducibility of small scale production parameters (particle size, size distribution, content of microparticles) was exemplary studied for the drug RMKP22. (C) 2000 Elsevier Science B.V. All rights reserved.
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