Journal
SCIENCE
Volume 287, Issue 5459, Pages 1830-1834Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5459.1830
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- NIDCD NIH HHS [DC-02174] Funding Source: Medline
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Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro(70), in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a Large and divergent family of taste receptors.
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