Journal
BIOMEDICAL CHROMATOGRAPHY
Volume 22, Issue 9, Pages 1028-1034Publisher
WILEY
DOI: 10.1002/bmc.1025
Keywords
enantiomeric separation; pharmaceutical preparation; atenolol; propranolol; L-tartaric acid; (R)-mandelic acid; (-)-erythromycin
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Funding
- University Grants Commission of India, New Delhi
- AvH-Stiftung, Bonn, Germany
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Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure L-tartaric acid, (R)-mandelic acid and (-)-erythromycin as chiral selectors. Different solvent systems were worked out to resolve the enantiomers. Spots were detected using iodine vapour. The TLC method was validated for linearity, limit of detection and limit of quantification. The influence of pH, temperature and concentration of chiral selector was studied. Copyright (C) 2008 John Wiley & Sons, Ltd.
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