Journal
PHYSIOLOGICAL GENOMICS
Volume 2, Issue 2, Pages 49-51Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.2000.2.2.49
Keywords
positional cloning; human disease models; mutagenesis screens; hematopoiesis
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The value of the zebrafish (Danio rerio) as a model for human disease has been substantiated by a number of recently published papers. Several zebrafish mutants with human'' diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebrafish have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establishment of new tools and access to the newly generated resources, the zebrafish is poised to serve as a novel model for human disease.
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