Journal
TOXICOLOGY LETTERS
Volume 112, Issue -, Pages 421-432Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-4274(99)00220-9
Keywords
autoimmune disease; drugs; chemicals; systemic lupus erythematosis; scleroderma; silica; toxic oil syndrome; eosinophilia-myalgia syndrome; systemic vasculitis
Categories
Ask authors/readers for more resources
Autoimmune connective tissue diseases are complex multisystems and may be life threatening. Their aetiology is unknown but genetic, hormonal and environmental factors are important. In systemic lupus erythematosus (SLE), factors such as UV light and drugs, including oestrogen, may trigger the disease; silica exposure may also be important. Scleroderma is associated with silica exposure and drugs such as bleomycin and pentazocine may induce scleroderma-like diseases. Organic solvents such as vinyl chloride and epoxy resins may also be associated with scleroderma-like illnesses. The toxic oil syndrome and eosinophila-myalgia syndrome are best known examples of connective tissue diseases induced by chemical exposure. The systemic vasculitides and in particular cutaneous vasculitis may be induced by drugs and possibly environmental factors. A number of autoimmune connective tissue diseases may therefore be associated with exposure to drugs, chemicals and environmental factors and the risks associated with these should be minimised where possible. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available