Journal
FEMS MICROBIOLOGY LETTERS
Volume 184, Issue 2, Pages 273-278Publisher
ELSEVIER SCIENCE BV
DOI: 10.1111/j.1574-6968.2000.tb09026.x
Keywords
quorum sensing; N-acyl-homoserine lactone; cystic fibrosis; Pseudomonas aeruginosa; Burkholderia cepacia
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The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis a ere analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However: in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
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