Journal
TOXICOLOGY LETTERS
Volume 112, Issue -, Pages 185-191Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-4274(99)00285-4
Keywords
reactive oxygen intermediates; cytokines; metabolic polymorphism; apoptosis; DNA repair; screening methods
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Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final manifestation of a multistep pathway, resulting in an imbalance between cell proliferation and cell death by apoptosis. The impact of certain confounding factors e.g. extent of inflammatory response, type of genotoxic event, antagonizing principles and genetic background are discussed in this article. Finally, methods to assess the inflammatory potential of chemicals are referred to. (C) 2000 Published by Elsevier Science ireland Ltd. All rights reserved.
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