Journal
BIOLOGICAL PSYCHIATRY
Volume 47, Issue 6, Pages 557-561Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(99)00167-5
Keywords
aging; Alzheimer's disease; dementia; diagnosis; longitudinal; magnetic resonance imaging
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Background: Due to the progressive nature of Alzheimer's disease (AD), it has been proposed that serial imaging studies tracking the course of progression might improve the diagnostic accuracy of AD. Methods: Longitudinal changes in hippocampal volumes were evaluated using magnetic resonance imaging (MRI) over a period of 3 years in 27 AD patients and 8 control subjects. Results: A statistically nonsignificant trend towards accelerated volume loss in the AD group compared to control subjects was observed During the study period, the average shrinkage of the hippocampal volume ranged from -2.2% to -5.8% in control subjects, and from -2.3% to -15.6% in AD patients. Conclusions: The observed changes at an individual level were small, and within the accuracy range of the measurements. Therefore, serial MRI of the hippocampus did not offer any advantage over a single MRI to support the diagnosis of AD in this study sample. (C) 2000 Society of Biological Psychiatry.
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