Journal
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
Volume 9, Issue 5, Pages 583-596Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-010-0199-5
Keywords
Bone tissue engineering; Scaffold; Tissue differentiation; Mechanoregulation; Finite element analysis
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Funding
- Spanish Ministry of Science and Innovation [MAT2005-07244]
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A computational model of mechanoregulation is proposed to predict bone tissue formation stimulated mechanically by overall dynamical compression within a porous polymeric scaffold rendered by micro-CT. Dynamic compressions of 0.5-5% at 0.0025-0.025 s(-1) were simulated. A force-controlled dynamic compression was also performed by imposing a ramp of force from 1 to 70 N. The model predicts homogeneous mature bone tissue formation under strain levels of 0.5-1% at strain rates of 0.0025-0.005 s(-1). Under higher levels of strain and strain rates, the scaffold shows heterogeneous mechanical behaviour which leads to the formation of a heterogeneous tissue with a mixture of mature bone and fibrous tissue. A fibrous tissue layer was also predicted under the force-controlled dynamic compression, although the same force magnitude was found promoting only mature bone during a strain-controlled compression. The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.
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