Journal
VACCINE
Volume 18, Issue 18, Pages 1932-1938Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(99)00445-4
Keywords
DNA vaccination; classical swine fever; protection
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Classical swine fever virus causes significant mortality and morbidity in commercial piggeries in many countries in Europe and Asia. The protective antigen, gp55, is highly conformation-dependent and thus killed virus or bacterially produced proteins are not protective. This report demonstrates that DNA vaccination with the gene encoding gp55 can provide protective immunity with inoculation of two doses of 25 mu g DNA or a single shot of 200 mu g. Furthermore, the DNA can be delivered intramuscularly or by a simple spring-loaded needleless inoculator. In addition it is shown that inoculation of the DNA at a single site conveys the same level of immunity as division of the dose between two sites. (C) 2000 Elsevier Science Ltd. All rights reserved.
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