Journal
BIOMATERIALS
Volume 183, Issue -, Pages 10-19Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.08.033
Keywords
Malignant bone tumor; Melanin-like nanoparticles; Bone-targeted delivery; Magnetic resonance imaging; Chemo-photothermal therapy
Funding
- National Natural Science Foundation of China [21725402, 81671822]
- National Key Research and Development Program of China [2016YFC0902100]
- Fok Ying Tong Education Foundation [151036]
- Science and Technology Commission of Shanghai Municipality [17XD1401600]
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Malignant bone tumors associated with aggressive osteolysis are currently hard to be cured by the clinical strategies. Nevertheless, nanomedicine might provide a promising therapeutic opportunity. Here, we developed a multifunctional melanin-like nanoparticle for bone-targeted chemo-photothermal treatment of malignant bone tumors. The particle was originally fabricated from alendronate-conjugated polydopamine nanoparticle (PDA-ALN) that exhibited excellent photothermal effect and high affinity to hydroxyapatite. PDA/Fe-ALN significantly enhanced the magnetic resonance contrast of the bone tumors in vivo, suggesting that more PDA-ALN accumulated at the osteolytic bone lesions in the tumors compared with the non-targeting PDA. Chemodrug SN38 was efficiently loaded on PDA-ALN, and the drug release could be triggered by near-infrared irradiation and acidic stimulus. Finally, the combined chemo-photothermal therapy efficiently suppressed the growth of bone tumors and reduced the osteolytic damage of bones at a mild temperature around 43 degrees C. This study provides an efficient and robust nanotherapeutics for the treatment of malignant bone tumors. '
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