Journal
NEUROREPORT
Volume 11, Issue 4, Pages 683-687Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200003200-00006
Keywords
basolateral amygdala; cingulate cortex; dentate gyrus; epsilon; GABA; limbic system; nucleus accumbens; prelimbic cortex; protein kinase C; receptor
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Funding
- NIAAA NIH HHS [T32 AA07576, R01 AA09981] Funding Source: Medline
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The distribution of PKC epsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKC epsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, and lowest in the prelimbic cortex and basolateral amygdala. Co-localization of PKC epsilon immunoreactivity with the GABA(A) receptor alpha(1), beta(2/3), and gamma(2) subunits varied by subunit and brain region examined, with the majority of co-localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKC epsilon may interact with GABA(A) receptors in a subunit- and region-specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKC epsilon modulates GABA(A) receptor function. NeuroReport 11:683-687 (C) 2000 Lippincott Williams & Wilkins.
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