Journal
BIOMATERIALS
Volume 181, Issue -, Pages 140-181Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.07.045
Keywords
SERS; Label-free; Nanotag; Imaging; Theranostics; Cancer
Funding
- CSIR Mission mode project, Nano-biosensor and microfluidics for healthcare [HCP-0012]
- Department of Biotechnology (DBT), Government of India [BT/PR14698/NNT/28/832/2015]
- Department of Science and Technology Nano Mission, Government of India [SR/NM/NS-1152/2016]
- Science and Engineering Research Board, DST, Government of India [PDF/2016/001391, PDF/2017/000078]
- University Grants Commission, Government of India
- CSIR
- Indian Council of Medical Research, Government of India
- DST
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Excellent multiplexing capability, molecular specificity, high sensitivity and the potential of resolving complex molecular level biological compositions augmented the diagnostic modality of surface-enhanced Raman scattering (SERS) in biology and medicine. While maintaining all the merits of classical Raman spectroscopy, SERS provides a more sensitive and selective detection and quantification platform. Non-invasive, chemically specific and spatially resolved analysis facilitates the exploration of SERS-based nano probes in diagnostic and theranostic applications with improved clinical outcomes compared to the currently available so called state-of-art technologies. Adequate knowledge on the mechanism and properties of SERS based nano probes are inevitable in utilizing the full potential of this modality for biomedical applications. The safety and efficiency of metal nanoparticles and Raman reporters have to be critically evaluated for the successful translation of SERS in to clinics. In this context, the present review attempts to give a comprehensive overview about the selected medical, biomedical and allied applications of SERS while highlighting recent and relevant outcomes ranging from simple detection platforms to complicated clinical applications. (C) 2018 Elsevier Ltd. All rights reserved.
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