Journal
JOURNAL OF CELL BIOLOGY
Volume 148, Issue 6, Pages 1131-1139Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.148.6.1131
Keywords
bcl10; filaments; mucosa-associated lymphoid tissue; NF-kappa B; scaffold
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Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-kappa B, Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-kappa B activation. We also show that cytoskeleton elements regulate bcl10 signaling, Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling.
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