Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 191, Issue 6, Pages 1069-1075Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.191.6.1069
Keywords
T1/ST2; T helper type 2 cells; immunoglobulin; pulmonary inflammation; mast cells
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We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T1/ST2 in T helper cell type 2 (Th2) responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of T1/ST2-deficient mice with those generated by wild-type mice. Using a primary pulmonary granuloma model, induced with Schistosoma mansoni eggs, we demonstrate that granuloma formation, characterized by eosinophil infiltration, is abrogated in T1/ST2-deficient mice. Furthermore, we clearly demonstrate that in the absence of T1/ST2 expression, the levels of Th2 cytokine production are severely impaired after immunization. Thus, in a secondary pulmonary granuloma model, draining lymph node cells from the T1/ST2-deficient animals produced significantly reduced levels of IL-4 and IL-5, despite developing granulomas of a magnitude similar to those of wild-type mice and comparable antigen-specific immunoglobulin isotype production. These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-Like cytokine responses and indicate that effector functions are inhibited in its absence.
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