Journal
BIOMATERIALS
Volume 35, Issue 9, Pages 2961-2970Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.12.038
Keywords
Microthrombosis; Fibrin; Multimodal nanoagents; Magnetic resonance imaging; Optical imaging
Funding
- National Natural Science Foundation of China [81370003, 81000043, 81001404]
- Zhuoxue program of Fudan University
- Natural Science Foundation of Shanghai Municipality of China [11ZR1406300]
- Central Universities Basic Research Funds for the Young Teachers Research Capacity Enhancement Projects of China [20520133291]
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Microthrombosis plays a key role in many cardiovascular diseases. Although it is not difficult to localize thrombus within large or middle-sized vessels, the noninvasive diagnostic regimen for the detection of microthrombus remains scarce. Here we developed a nanoagent by conjucting superparamagnetic iron-oxide nanoparticle with fluorophore and a targeting element, CREKA, a peptide with special affinity for fibrin. In a rat model of myocardial ischemia-reperfusion (MI/R), the multimodal nanoagents were readily and selectively accumulated within microthrombosis, which was detectable by both magnetic resonance and optical imaging modalities. The fibrin-targeted nanoagent could be expected to have utility not only in molecular imaging of fibrin, understanding the mechanisms of microcirculation disorders, but also in targeted therapy with fibrinolytic agents. (C) 2013 Elsevier Ltd. All rights reserved.
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