Journal
BIOMATERIALS
Volume 35, Issue 11, Pages 3489-3496Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.01.027
Keywords
Micelle; In vivo stability; Delivery; FRET; Self-assembly
Funding
- National Cancer Institute [P30-CA14051]
- internal David H. Koch Nanoparticle grant
- NIH [5 U54 CA151884-02 (CCNE)]
- National Science Foundation Graduate Research Fellowship
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Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Forster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management. (C) 2014 Elsevier Ltd. All rights reserved.
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