Rapid synthesis of phosphorus-containing dendrimers with controlled molecular architectures: First example of surface-block, layer-block, and segment-block dendrimers issued from the same dendron

A third generation dendron possessing one activated vinyl group linked to the con and 16 chlorines linked to the surface has been functionalized with various groups at the core (primary amine, phosphine, or azide), and on the surface (aldehyde, tertiary amine, or nitrile). These functionalized dendrons are used as building blocks for the synthesis of several complex dendritic architectures, obtained through core-core, core-surface, or core-core-surface-core couplings using very simple one-step reactions between these functions, such as Michael additions between vinyl and primary amino groups or Staudinger reactions between phosphines and azides. These reactions finally induce the formation of layer-block dendrons, a surface-block dendrimer, a layer-block dendrimer, a layered surface-block dendrimer: and a segment-block dendrimer, all issued from the same original dendron.