Journal
BIOMATERIALS
Volume 35, Issue 10, Pages 3331-3339Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.12.095
Keywords
Co-delivery system; Layered double hydroxide; Electrostatic assembly; Apoptosis
Funding
- ARC Future Fellowship [FT120100813]
- ARC DP [DP120104792]
- University of Queensland Postdoctoral Fellowship
- UQ early-career-research grant
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In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment. (C) 2014 Elsevier Ltd. All rights reserved.
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