Journal
FEBS LETTERS
Volume 470, Issue 2, Pages 113-117Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01302-8
Keywords
neurotrophin; human umbilical vein endothelial cell; cAMP; platelet
Ask authors/readers for more resources
Brain-derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair after injury, BDNF has been detected in rat and human blood, but the source of circulating BDNF is not established, BDNF messenger and peptide were detected in cultured cells and in the culture medium of human umbilical vein endothelial cells, The expression of BDNF was up-regulated by elevation of intracellular cAMP and down-regulated by Ca2+ ionophore, bovine brain extract and laminar fluid shear stress. These results suggest that vascular endothelial cells may contribute to circulating BDNF. (C) 2000 Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available