Journal
NEUROSCIENCE LETTERS
Volume 282, Issue 3, Pages 193-196Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)00901-0
Keywords
fibromyalgia; positron emission tomography; regional cerebral blood flow; natural killer cell activity; neuroimmunology
Categories
Ask authors/readers for more resources
To study relations between neural and immune activity in patients with chronic pain, we correlated regional cerebral blood flow measured with [O-15]butanol positron emission tomography to immune function in five patients with fibromyalgia. Partly replicating previous data in healthy volunteers, natural killer cell activity correlated negatively with right hemisphere activity in the secondary somatosensory and motor cortices as well as the thalamus. Moreover, natural killer cell activity was negatively and bilaterally related to activity in the posterior cingulate cortex. Thus, immune parameters were related to activity in brain areas involved in pain perception, emotion, and attention. Implicated from a small study population, these strong neuro-immune associations are discussed in view of recent findings concerning mechanisms and adaptive values in immuno-cortical communication and regulation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available