Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 392, Issue 1-2, Pages 19-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00115-1
Keywords
CTGF (connective tissue growth factor); TGF-beta (transforming growth factor beta); apoptosis; caspase; atherosclerosis
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Connective tissue growth factor (CTGF) stimulates proliferation of fibroblasts and endothelial cells, but nothing is known about its role in smooth muscle cells. In this study, the effects of recombinant human CTGF (r-hCTGF, 0.5-10 mu g/ml) on cultured human aortic vascular smooth muscle cells were investigated. r-hCTGF significantly reduced cell viability, increased apoptosis, and augmented caspase 3 activity. Moreover, r-hCTGF-induced apoptosis was significantly inhibited by an antibody to CTGF and a caspase-3 inhibitor, Z-Asp(Ome)-Glu-(Ome)Val-Asp(Ome)-FMK. These results suggest that r-hCTGF activates caspase 3 and induces apoptosis. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
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