Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 275, Issue 12, Pages 8889-8894Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.275.12.8889
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The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H-C and of H-C soaked with carbohydrates reveal a number of binding sites and protide insight into the possible mode of ganglioside binding.
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