Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

The development of photothermal agents (PTAs) with good stability, low toxicity, highly targeting ability and photothermal conversion efficiency is an essential pre-requisite to near-infrared photothermal therapy (PTT) in vivo. Herein, we report the readily available PEGylated Fe@Fe3O4 NPs, which possess triple functional properties in one entity - targeting, PTT, and imaging. Compared to Au nanorods, they exhibit comparable photothermal conversion efficiency (similar to 20%), and much higher photothermal stability. They also show a high magnetization value and transverse relaxivity (similar to 156 mM(-1) s(-1)), which should be applied for magnetic targeting MRI With the Nd-Fe-B magnet (0.5 T) beside the tumour for 12 h on the xenograft HeLa tumour model, PEGylated Fe@Fe3O4 NPs exhibit an obvious accumulation. In tumour, the intensity of MRI signal is similar to three folds and the increased temperature is similar to two times than those without magnetic targeting, indicating the good magnetic targeting ability. Notably, the intrinsic high photothermal conversion efficiency and selective magnetic targeting effect of the NPs in tumour play synergistically in highly efficient ablation of cancer cells in vitro and in vivo. (C) 2014 Elsevier Ltd. All rights reserved.