Journal
BIOMATERIALS
Volume 35, Issue 30, Pages 8605-8612Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.06.060
Keywords
Extracellular matrix (ECM); Macrophage; Immune response; Immunomodulation; Progenitor cell; Stem cell
Funding
- NIH [F31AG042199]
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The regenerative healing response of injured skeletal muscle is dependent upon a heterogeneous population of responding macrophages, which show a phenotypic transition from the pro-inflammatory M1 to the alternatively activated and constructive M2 phenotype. Biologic scaffolds derived from mammalian extracellular matrix (ECM) have been used for the repair and reconstruction of a variety of tissues, including skeletal muscle, and have been associated with an M2 phenotype and a constructive and functional tissue response. The mechanism(s) behind in-vivo macrophage phenotype transition in skeletal muscle and the enhanced M2:M1 ratio associated with ECM bioscaffold use in-vivo are only partially understood. The present study shows that degradation products from ECM bioscaffolds promote alternatively activated and constructive M2 macrophage polarization in-vitro, which in turn facilitates migration and myogenesis of skeletal muscle progenitor cells. (C) 2014 Elsevier Ltd. All rights reserved.
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