Journal
BIOMATERIALS
Volume 35, Issue 29, Pages 8374-8384Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.05.094
Keywords
Metastatic breast cancer; Gold nanorods; Doxorubicin; Photothermal ablation; Chemotherapy
Funding
- National Basic Research Program of China [2013CB932704, 2010CB934000, 2012CB932502]
- National Natural Science Foundation of China [81373359, 81270047, 21305047]
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Despite the exciting advances in cancer therapy over past decades, tumor metastasis remains the dominate reason for cancer-related mortality. In present work, DNA-wrapped gold nanorods with doxorubicin (DOX)-loading (GNR@DOX) were developed for treatment of metastatic breast cancer via a combination of chemotherapy and photothermal ablation. The GNR@DOX nanoparticles induced significant temperature elevation and DOX release upon irradiation with near infrared (NIR) light as shown in the test tube studies. It was found that GNR@DOX nanoparticles in combination with laser irradiation caused higher cytotoxicity than free DOX in 4T1 breast cancer cells. Animal experiment with an orthotropic 4T1 mammary tumor model demonstrated that GNR@DOX nanoplatform significantly reduced the growth of primary tumors and suppressed their lung metastasis. The Hematoxylin and Eosin (H&E) and immunohistochemistry (IHC) staining assays confirmed that the tumor growth inhibition and metastasis prevention of GNR@DOX nanoparticles were attributed to their abilities to induce cellular apoptosis/necrosis and ablate intratumoral blood vessels. All these results suggested a considerable potential of GNR@DOX nanoplatform for treatment of metastatic breast cancer. (C) 2014 Elsevier Ltd. All rights reserved.
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