Journal
BIOMATERIALS
Volume 35, Issue 13, Pages 4146-4156Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.01.068
Keywords
Upconversion; ZnPc; Photodynamic therapy; Covalent assembly
Funding
- NSF of China [11174277, 11374297, 21304084, 51372096, 61275202]
- CAS of China
- KNAW of the Netherlands
- IOP program of the Netherlands
- John van Geuns foundation
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Recent advances in NIR triggering upconversion-based photodynamic therapy have led to substantial improvements in upconversion-based nanophotosensitizers. How to obtain the high efficiency of singlet oxygen generation under low 980 nm radiation dosage still remains a challenge. A highly efficient nanophotosensitizer, denoted as UCNPs-ZnPc, was constructed for photodynamic therapy, which is based on near infrared (NIR) light upconversion nanoparticle (UCNP) and Zn(II)-phthalocyanine (ZnPc) photosensitizer (PS). The high 102 production efficiency came from the enhancement of the 660 nm upconversion emission of NaYF4:Yb3+, Er3+ UCNP with 25% Yb3+ doping, covalent assemblage of UCNP and ZnPc which significantly shortened the distance and enhanced the energy transfer between the two. The high O-1(2) production led to a secure and efficient PDT treatment, as evidenced by the in vivo test where UCNPs-ZnPc of 50 mg per kg body weight was locally injected into the liver tumor in mice, a low 980 nm radiation dose of 351 j/cm(2) (039 W/cm(2)) and short irradiation duration of 15 min were sufficient to perform image-guided PDT and caused the liver tumor inhibitory ratio of approximately 80.1%. Histological analysis revealed no pathological changes and inflammatory response in heart, lung, kidney, liver or spleen. (c) 2014 Elsevier Ltd. All rights reserved.
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