Journal
BIOMATERIALS
Volume 35, Issue 5, Pages 1572-1583Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.11.007
Keywords
Selenium nanoparticles; Angiogenesis; Fluorescence imaging; In vivo distribution; Targeted delivery
Funding
- National Natural Science Foundation of China [20871056, 21171070, 21371075]
- Planned Item of Science and Technology of Guangdong Province [c1011220800060]
- Fundamental Research Funds for the Central Universities
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Here we reported the high tumor targeting efficacy of luminescent Ru(II)-thiols protected selenium nanoparticles (Ru-MUA@Se). We have shown that a dual-target inhibitor Ru-MUA@Se directly suppress the tumor growth but also block blood-vessel growth. We also determined that the nanoparticles entered the cells via clathrin-mediated endocytosis pathway. In a xenograft HepG2 tumor model, we found that Ru-MUA@Se effectively inhibited tumor angiogenesis and suppressed tumor growth with low side effects using metronomic chemotherapy with Ru-MUA@Se. In vivo investigation of nanoparticles on nude mice bearing HepG2 cancer xenografts confirmed that Ru-MUA@Se nanoparticles possessed high tumor-targeted fluorescence imaging, exhibited enhanced antitumor efficacy and decreased systemic toxicity. Moreover, Ru-MUA@Se not only significantly induced dose-dependent disruption of mitochondrial membrane potential in HepG2 cells after 24 h treatment, but it also enhanced reactive oxygen species (ROS) generation. Our results suggest that the potential application of these Ru-MUA@Se nanoparticles in targeting cancer imaging and chemotherapy. (C) 2013 Elsevier Ltd. All rights reserved.
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