Journal
BIOMATERIALS
Volume 35, Issue 1, Pages 287-293Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.09.084
Keywords
Oil-in-water emulsion; Polypyrrole capsules; Perfluorooctylbromide; Ultrasound imaging; Photothermal therapy
Funding
- National Natural Science Foundation for Distinguished Young Scholars [81225011]
- State Key Program of National Natural Science of China [81230036]
- National Natural Science Foundation of China [21273014, 81371580]
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A versatile oil-in-water emulsion method has been explored for constructing water-dispersible polypyrrole (PPy) nano-/microcapsules with a soluble PPy complex as multifunctional photothermal agents for tumor ablation. In this work, both PPy nanocapsules (280.4 +/- 79.0 nm) and microcapsules (1.31 +/- 0.45 mu m) with liquid perfluorooctylbromide (PFOB) core could be obtained by simply tuning the process energy for emulsion formation from ultrasonication to homogenization. Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. Thus, it is anticipated that fine-tuning of the other encapsulated drugs or functional materials in PPy capsules would foster avenues for the development of multifunctional platforms for cancer treatments. (C) 2013 Elsevier Ltd. All rights reserved.
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