Journal
BIOMATERIALS
Volume 35, Issue 16, Pages 4627-4635Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.02.042
Keywords
MRI (magnetic resonance imaging); Optical imaging; Nanoparticle; Stem cell; Ischaemic stroke; Nerve regeneration
Funding
- National Natural Science Foundation [81071028, 81371607]
- National Science Fund for Distinguished Young Scholars of China [51225305]
- Central Universities of China [09ykpy04]
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Stem cell therapies are promising strategies for the treatment of stroke. However, their clinical translation has not been fully realized due, in part, to insufficient ability to track stem cell migration and survival longitudinally over long periods of time in vivo. In this work, we synthesized a new class of manometersized cationic polymersomes loaded with superparamagnetic iron oxide nanoparticles and quantum dots for in vivo dual-modal imaging of stem cells. The results demonstrated that the synthesized cationic polymersomes can act as an effective and safety carrier to transfer image labels into neural stem cells, upon which the distribution and migration of grafted stem cells could be monitored by MR imaging up to 6 weeks and by fluorescence imaging within 4 weeks in the context of ischaemic brain injury. Cationic polymersomes hold great promise in the longitudinal monitoring of transplanted stem cells by using dual-modal MRI and optical imaging. (C) 2014 Elsevier Ltd. All rights reserved.
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