Journal
BIOMATERIALS
Volume 35, Issue 16, Pages 4601-4609Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.02.033
Keywords
Antibacterial surfaces; Silver nanoparticles; Infections; Innate inflammatory response; Cytotoxicity; Medical devices
Funding
- Australian Research Council [FT100100292]
- Australian Research Council [FT100100292] Funding Source: Australian Research Council
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Infections arising from bacterial adhesion and colonization on medical device surfaces are a significant healthcare problem. Silver based antibacterial coatings have attracted a great deal of attention as a potential solution. This paper reports on the development of a silver nanoparticles based antibacterial surface that can be applied to any type of material surface. The silver nanoparticles were surface engineered with a monolayer of 2-ercaptosuccinic acid, which facilitates the immobilization of the nanoparticles to the solid surface, and also reduces the rate of oxidation of the nanoparticles, extending the lifetime of the coatings. The coatings had excellent antibacterial efficacy against three clinically significant pathogenic bacteria i.e. Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa. Studies with primary human fibroblast cells showed that the coatings had no cytotoxicity in vitro. Innate immune studies in cultures of primary macrophages demonstrated that the coatings do not significantly alter the level of expression of pro-inflammatory cytokines or the adhesion and viability of these cells. Collectively, these coatings have an optimal combination of properties that make them attractive for deposition on medical device surfaces such as wound dressings, catheters and implants. (C) 2014 Elsevier Ltd. All rights reserved.
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