Journal
BIOMATERIALS
Volume 35, Issue 33, Pages 9114-9125Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.07.040
Keywords
Silver nanoparticles; Titanium; Biofilm; Cytotoxicity; Plasma immersion ion implantation
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- Interdisciplinary (Engineering-Medical) Research Fund of Shanghai Jiao Tong University [YG2011MS30]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201206SIC]
- National Natural Science Foundation of China [81271962, 81301571, 31100675]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) CityU [112212]
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Prevention of periprosthetic infection (PPI) by inhibiting biofilm formation on prostheses is crucial to orthopedic surgery. In this work, silver nanoparticles (Ag NPs) are fabricated in situ and immobilized on titanium by silver plasma immersion ion implantation (PIII). The anti-biofilm activity rendered by the immobilized Ag NPs is assessed using Staphylococcus epidermidis, a biofilm producing strain, in vitro and in vivo. The immobilized Ag NPs show no apparent cytotoxicity but reduce biofilm formation in vitro by inhibiting bacteria adhesion and icaAD transcription. The immobilized Ag NPs offer a good defense against multiple cycles of bacteria attack in vitro, and the mechanism is independent of silver release. Radiographic assessment, microbiological cultures, and histopathological results demonstrate the ability of the functionalized surface against bacterial infection to reduce the risk of implant-associated PPI. (C) 2014 Elsevier Ltd. All rights reserved.
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