Journal
BIOMATERIALS
Volume 34, Issue 19, Pages 4643-4654Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.02.063
Keywords
Theranostics; Silica; Gold nanocluster; Chlorin e6 (Ce6); Fluorescence imaging; Photodynamic therapy
Funding
- National Key Basic Research Program (973 Project) [2010CB933901, 2013CB733802]
- National Science Foundation of China [81171399, 81272987, 51102258, 31170961, 81101101, 81230033, 81101077]
- Jiangsu Province Foundation [BK2011166, BE2012622, BL2012031, RC2011095]
- Zhejiang Province Foundation [LY12H11011]
- Chinese Academy of Sciences professorship for Senior International Scientists [2011T2J06]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
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Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens. In this work, a photo-theranostic agent based on chlorin e6 (Ce6) photosensitizer-conjugated silica-coated gold nanoclusters (AuNC5@SiO2 Ce6) is strategically designed and prepared for fluorescence imaging-guided photodynamic therapy (PDT). The AuNCs@SiO2 Ce6 shows the following features: i) high Ce6 photosensitizer loading; ii) no non-specific release of Ce6 during its circulation; iii) significantly enhanced cellular uptake efficiency of Ce6, offering a remarkably improved photodynamic therapeutic efficacy compared to free Ce6; iv) subcellular characterization of the nanoformula via both the fluorescence of Ce6 and plasmon luminescence of AuNCs; v) fluorescence imaging-guided photodynamic therapy (PDT). This photo-theranostics owns good stability, high water dispersibility and solubility, non-cytotoxicity, and good biocompatibility, thus facilitating its biomedical applications, particularly for multi-modal optical, CT and photoacoustic (PA) imaging-guided PDT or sonodynamic therapy. Published by Elsevier Ltd.
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