Journal
BIOMATERIALS
Volume 34, Issue 12, Pages 3150-3158Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.01.051
Keywords
Mesoporous silica-encapsulated gold nanorods; Photothermal therapy; Chemotherapy; Synergistic effect
Funding
- National Key Basic Research Program [2013CB932502]
- National Science and Technology Major Project [2012ZX09304004]
- National Natural Science Foundation of China [81001404]
- Doctor Fund
- Ministry of Education of China [20100071120050]
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Mesoporous silica-encapsulated gold nanorods (GNRs@mSiO(2)) have great potential both in photothermal therapy and drug delivery. In this paper, we firstly developed GNR5@mSiO(2) as a synergistic therapy tool for delivery heat and drug to the tumorigenic region. We studied the ablation of tumor both in vitro and in vivo by the combination of photothermal therapy and chemotherapy using doxorubicin (DOX)-loaded GNR5@rnSiO(2). Significantly greater cell killing was observed when A549 cells incubated with DOX-loaded GNR5@mSiO(2) were irradiated with near-infrared (NIR) illumination, attributable to both GNRs@mSiO(2)-mediated photothermal ablation and cytotoxicity of light-triggered DOX release. We then performed in vivo therapy studies and observed a promising tumor treatment. Compared with chemotherapy or photothermal treatment alone, the combined treatment showed a synergistic effect, resulting in higher therapeutic efficacy. Furthermore, the lower systematic toxicity of GNRs@mSiO(2) has been validated. (C) 2013 Elsevier Ltd. All rights reserved.
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