Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1470, Issue 2, Pages M55-M62Publisher
ELSEVIER
DOI: 10.1016/S0304-419X(00)00002-0
Keywords
-
Categories
Ask authors/readers for more resources
Discovered in 1986 as a DNA binding activity that recognized the immunoglobulin light chain intronic enhancer, NF-kappa B has been studied intensively for its role in controlling expression of genes involved in immune and inflammatory function [1,2]. However, more recently, NF-kappa B has been implicated in controlling cell growth and oncogenesis. The link between NF-kappa B and cancer stems, in part, from the fact that this transcription factor is capable of inducing gene products that control proliferative responses and that suppress apoptotic cascades, such as those induced by tumor necrosis factor (TNF), expression of oncoproteins, and genotoxic stress. This latter observation is likely to be important in developing new approaches aimed at improving the efficacy of cancer chemotherapy. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available