Journal
BIOMATERIALS
Volume 34, Issue 34, Pages 8798-8807Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.07.084
Keywords
Therapeutic nanomedicine; Dual-intelligent; Gold nanoparticle; Cancer imaging
Funding
- National Natural Science Foundation of China [51125014, 51233003, 21204068]
- Ministry of Science and Technology of China [2011CB606202]
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A novel strategy to construct a therapeutic system based on functionalized AuNPs which can specifically respond to tumor microenvironment was reported. In the therapeutic system, doxorubicin was conjugated to AuNPs via thiol-Au bond by using a peptide substrate, CPLGLAGG, which can be specifically cleaved by the protease. In vivo study shows that after injection of the functionalized AuNPs to the tumor-bearing mice, the over-expressed protease of MMP-2 in tumor tissue and intracellular GSH can lead to the rapid release of the anti-tumor drug (doxorubicin) from the functionalized AuNPs to inhibit tumor growth and realize fluorescently imaging simultaneously. The functionalized AuNPs with tumor-triggered drug release property can further improve the efficacy and reduce side effects significantly. (C) 2013 Elsevier Ltd. All rights reserved.
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