Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 7, Pages 3422-3427Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.070046397
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- NHLBI NIH HHS [R01 HL057516, HL57516, R37 HL053354, HL53354, R01 HL053354, HL60911] Funding Source: Medline
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Animal studies and preliminary results in humans suggest that lower extremity and myocardial ischemia can be attenuated by treatment with angiogenic cytokines. The resident population of endothelial cells that is competent to respond to an available level of angiogenic growth factors, however, may potentially limit the extent to which cytokine supplementation enhances tissue neovascularization. Accordingly, we transplanted human endothelial progenitor cells (hEPCs) to athymic nude mice with hindlimb ischemia, Blood flow recovery and capillary density in the ischemic hindlimb were markedly improved, and the rate of limb loss was significantly reduced. Ex vivo expanded hEPCs may thus have utility as a supply-side strategy for therapeutic neovascularization.
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