Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 393, Issue 1-3, Pages 113-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00007-8
Keywords
nicotinic acetylcholine receptor
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Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels, which are involved in a wide range of neuronal functions. During the past decade, a large number of nicotinic acetylcholine receptor subunits have been cloned and showed a discreet yet overlapping distribution pattern. Recently, several groups have produced mutant mice lacking specific nicotinic acetylcholine receptor subunits. In this review, we focus on how the study of these knockout mouse models has advanced our understanding of the role individual nicotinic acetylcholine receptor subunits play in the function and composition of endogenous receptors and the diverse pharmacological actions of nicotine in the mammalian nervous system. (C) 2000 Elsevier Science B.V. All rights reserved.
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