Journal
BIOMATERIALS
Volume 34, Issue 36, Pages 9124-9133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.08.022
Keywords
Micelles; Indocyanine green; Cypate; Near-infrared fluorescent imaging; Photothermal therapy
Funding
- National Basic Research Program [2012CB932500, 2014CB931903]
- National Natural Science Foundation of China [81202472, 51225305, 81273462]
- priority academic program development of Jiangsu higher education institutions (PAPD)
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It is an emerging focus to explore a theranostic nanocarrier for simultaneous cancer imaging and therapy. Herein, we demonstrate a theranostic micelle system for cancer near infrared fluorescent (NIRF) imaging with enhanced signal to noise ratio and superior photothermal therapy. The copolymers consisting of monomethoxy poly( ethylene glycol) and alkylamine-grafted poly(L-aspartic acid) are assembled with carbocyanine dyes into theranostic micelles, which exhibit small size, high loading capacity, good stability, sustained release behavior, and enhanced cellular uptake. The micelles achieve the preferable biodistribution and long-term retention of carbocyanine dyes at tumor, which result in enhanced NIRF imaging by generating stable retention of NIRF signals at both hypenrascular and hypovascular tumors during a long-term imaging period of up to 8 day, accompanying with negligible noise at normal tissues. The photostability of carbocyanine dye (Cypate) plays an important role for long-term cancer imaging with enhanced SNR. Moreover, the micelles exhibit severe photothermal damage on cancer cells via the destabilization of subcellular organelles upon photoirradiation, causing superior photothermal tumor regress. The micelles act as a powerful theranostic nanocarrier for simultaneous cancer imaging with high contrast and superior photothermal therapy. (C) 2013 Elsevier Ltd. All rights reserved.
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