Journal
BIOMATERIALS
Volume 34, Issue 27, Pages 6306-6317Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.05.009
Keywords
Nonlinear elasticity; Poly(glycerol sebacate); Poly(lactic acid); Core/shell electrospinning; Hirschsprung disease; Enteric nervous system progenitor cells
Funding
- Australian National Health Medical Research Council [APP1050692, ARCDP130101384]
- Victorian Government
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An efficient delivery system is critical for the success of cell therapy. To deliver cells to a dynamic organ, the biomaterial vehicle should mechanically match with the non-linearly elastic host tissue. In this study, nonlinearly elastic biomaterials have been fabricated from a chemically crosslinked elastomeric poly(glycerol sebacate) (PGS) and thermoplastic poly(L-lactic add) (PLLA) using the core/shell electrospinning technique. The spun fibrous materials containing a PGS core and PLLA shell demonstrate J-shaped stress-strain curves, having ultimate tensile strength (UTS), rupture elongation and stiffness constants of 1 +/- 0.2 MPa, 25 +/- 3% and 12 +/- 2, respectively, which are comparable to skin tissue properties reported previously. Our ex vivo and in vivo trials have shown that the elastomeric mesh supports and fosters the growth of enteric neural crest (ENC) progenitor cells, and that the cell-seeded elastomeric fibrous sheet physically remains in intimate contact with guts after grafting, providing the effective delivery of the progenitor cells to an embryonic and post-natal gut environment. (C) 2013 Elsevier Ltd. All rights reserved.
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